Iron Oxide Nanoparticles Synthesis and Applications

Iron oxide nanoparticles have attracted a lot of attention in the last two decades due to their promising physical and biological properties. Nowadays, they are used in a broad range of biomedical applications, such as magnetic resonance imaging (MRI), magnetic particle imaging (MPI), homogeneous magnetic bioassays (e.g. magnetorelaxometry, ac susceptibility and rotating magnetic field) and magnetic hyperthermia. Fabrication of functional iron oxide nanoparticles with well defined size and shape distribution has been always a great challenge.


Here in EMG, we synthesize highly monodisperse iron oxide nanoparticles via thermal decomposition of iron-oleate precursor. We are able to vary the particle diameter from 13 to 24 nm while the particle size deviation retains constant, yet less than 10%. The high resolution transmission electron microscopy images of the synthesized particles are shown in figure X. Our next challenge is the transfer of hydrophobic nanoparticles into aqueous fluids using hydrophilic poly (ethylene glycol) derivative compounds for being used in magnetic detection of target molecules and antibodies via the manipulation of the particles in dynamic magnetic fields (e.g. alternative and rotating).